منابع مشابه
A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors.
The subrenal capsule assay may predict to which anticancer drug a given patient's tumor is sensitive and may also be used to screen new anticancer drugs. The present study documents that the use of this model requires a histological assessment of both the exploitability of a subrenal capsule assay and the extent of drug-induced antitumor lesions. Thirty-five tumors from 34 patients with solid t...
متن کاملFibrin Clot Subrenal Capsule Assay Rapid Growth of Human Cancer Cells in a Mouse Model with
Rapid in vivo growth of cultured human cancer or leukemia cells was achieved by implantation into the subrenal capsule of mice. A solid structure, necessary for accurate implantation and measurement of tumor growth in this model, was provided by stepwise addition of fibrinogen and thrombin to the tumor cells, leading to rapid enzymatic formation of a solid tumor-fibrin matrix. Human leukemia an...
متن کاملRapid growth of human cancer cells in a mouse model with fibrin clot subrenal capsule assay.
Rapid in vivo growth of cultured human cancer or leukemia cells was achieved by implantation into the subrenal capsule of mice. A solid structure, necessary for accurate implantation and measurement of tumor growth in this model, was provided by stepwise addition of fibrinogen and thrombin to the tumor cells, leading to rapid enzymatic formation of a solid tumor-fibrin matrix. Human leukemia an...
متن کامل[Chemosensitivity study using subrenal capsule assay in urinary transitional cell carcinomas].
A subrenal capsule assay (SRCA) was performed on 34 fresh surgical specimens from 31 urinary transitional cell carcinoma (TCC) patients. On day 6, 97.7% of explants were detected macroscopically and tumor cells were present in 45.6% of all explants microscopically. In control groups, there was a negative correlation between the change in explant size (delta TS) and the percentage of the area of...
متن کاملComparison of the subrenal capsule assay and succinate dehydrogenase inhibition test as drug sensitivity tests for cancer.
The same chemotherapeutic agents were tested against fresh surgical explants of solid tumors obtained from 50 patients using the in vivo subrenal capsule (SRC) assay and the in vitro succinate dehydrogenase inhibition (SDI) test in comparison. Control growth adequate to meet evaluable assay criteria was obtained in 36 of the 50 tumors tested in the SRC assay (72.0%). In the SDI test, 46 of 50 t...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1987
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1928.78.4_643